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Cyclosporine is indicated for the treatment of atopic dermatitis in dogs. Cyclosporine can also be used as an aid in the treatment of perianal fistulae in dogs. A perianal fistula is a syndrome of inflammation, ulceration and draining sinuses in the perianal (around the anus) region of dogs, particularly German Shepherds. It is thought to be an immune-mediated condition.